Detalhe da pesquisa
1.
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.
Genes Dev
; 34(21-22): 1452-1473, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33060135
2.
The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
J Biol Chem
; 300(1): 105501, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016516
3.
Discovery and resistance mechanism of a selective CDK12 degrader.
Nat Chem Biol
; 17(6): 675-683, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753926
4.
1,6-Hexanediol, commonly used to dissolve liquid-liquid phase separated condensates, directly impairs kinase and phosphatase activities.
J Biol Chem
; 296: 100260, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33814344
5.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Nat Chem Biol
; 16(11): 1199-1207, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747809
6.
Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.
Nat Chem Biol
; 17(3): 361, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33452497
7.
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
J Exp Med
; 220(1)2023 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36315050
8.
Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Science
; 380(6642): eabn7625, 2023 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37079685
9.
Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.
Front Immunol
; 13: 917232, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35979364
10.
Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
Nat Commun
; 12(1): 6607, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34785661
11.
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Eur J Med Chem
; 221: 113481, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33945934
12.
LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.
Nat Biotechnol
; 39(12): 1556-1562, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34188222
13.
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.
Nat Biotechnol
; 40(8): 1295, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35851378